Selected Peer-Reviewed Papers from Biotia Team Members:

Our study with Weill Cornell Medicine on "Comparison of five testing modalities for the assessment of patient environment cleanliness” demonstrates the utility of NGS for environmental testing. See our poster from IDWeek 2018.

Read our manuscript, work by our co-founders, lead by our CEO Dr. O’Hara, published in the journal Microbiome. The first metagenomic study of US ambulances.

Team members tested novel disinfection technology by studying ozone treatment for “Elimination of bacteria in medical environments”. Pre-print on bioRxiv.

Relevant work by our co-founder Dr. Mason’s lab:

Mapping the microbes of the NYC Subway in the Pathomap Project. “Geospatial Resolution of Human and Bacterial Diversity with City-Scale Metagenomics”. Read more…

The MetaSUB International Consortium. “The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium inaugural meeting report”. Read more…

Important work on the “International Standards for Genomes, Transcriptomes, and Metagenomes”. Read more…

“Comprehensive benchmarking and ensemble approaches for metagenomic classifiers”. Work conducted by co-founders Dr. Ounit and Dr. Mason. Read more…

“Communicating the promise, risks, and ethics of large-scale, open space microbiome and metagenome research”. Read more…

Relevant work by our co-founder and CTO, Dr. Ounit:

A faster, more accurate and scalable analysis of genomic (for genome assembly, BAC libraries annotation, chimera and contaminants detection, etc.) and metagenomic data (for environmental and clinical analysis) with the CLARK framework,

and its algorithmic extension for more sensitivity, without loss of precision and scalability, in the context of metagenomics. Read more…

An example of integration of the CLARK framework in genomics: The construction of the final reference genome of barley, which was featured on the cover of Nature journal. Read more…

Optimizing data-structure for database searching, read mapping and sequence comparison in genomics and metagenomics. Read more…

A faster and more efficient computational method for methylation analysis with bisulfite-treated reads. Read more…

Relevant work by our CMO, Dr. Nagy-Szakal:

D Nagy-Szakal et al. “Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics”. Scientific Reports, 2018, 3;8(1):10056.

Nagy-Szakal D et al. “Fecal Metagenomic Profiles in Subgroups of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome”. Microbiome, 2017, 5(1):44

Shah R, Cope JL, Nagy-Szakal D, Dowd S, Versalovic J, Hollister EB, Kellermayer R. “Composition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis. Gut Microbes”. 2016;7(5):384-96.    

Chehoud C, Dryga A, Hwang Y, Nagy-Szakal D, Hollister E, Luna RA, Versalovic J, Kellermayer R, Bushman FD. “Transfer of viral communities between human individuals during fecal microbiota transplantation”. MBio, 2016;7(2):e00322

Kellermayer R, Nagy-Szakal D, Harris RA, Luna RA, Pitashny M, Schady D, Mir SAV, Lopez, ME, Gilger MA, Belmont J, Hollister EB, Versalovic J. “Serial Fecal Microbiota Transplantation Alters Mucosal Gene  Expression in Pediatric Ulcerative Colitis”. American Journal of Gastroenterology, 2015; 110(4):604-6.